FOS, Bacteria, Colon Cancer
In this video, Daniel Nadeau spends about 23 minutes speaking on "FOS, Bacteria, Colon Cancer" at the 27th Annual Cancer Convention held on Labor Day weekend by the Cancer Control Society.
About Daniel Nadeau
DANIEL NADEAU, M.D., Tufts School of Medicine, is clinical director of the Diabetes Endocrine Nutrition Center, and the principal investigator for several diabetes clinical trials. He is also a medical reporter for WABI TV in Bangor, Maine. Dr. Nadeau received his M.S. Degree from Tufts University School of Nutrition.
Dr. Nadeau has also been associate medical director for Abbott International, a major pharmaceutical company, where he studied the design and implementation of nutritional supplements. While at Abbott, Dr. Nadeau researched the role of short-chain fructooligosaccharides (FOS) in health and disease. FOS is a naturally occurring carbohydrate that feeds beneficial bacteria in the gastrointestinal tract. By feeding the "good" bacteria, it may help prevent the overgrowth of "bad" bacteria such as pathogenic E.coli. His studies have shown that supplementation with FOS may reduce levels of toxic compounds, implicated as possible catalysts in the development of colon cancer. In one medical study, FOS was shown to significantly reduce 2 enzymes implicated in the formation of cancer.
For the past three years, he has received the National Research Service Award sponsored by the U.S. Department of Health and Human Services. In this video, Dr. Nadeau speaks on FOS & Friendly Bacteria in the Control of Colon Cancer.
Transcription
Well, it's really wonderful to be here. I like to thank specifically the Lorraine Rosenthal for inviting me. She heard me speak several months ago and thought that would be appropriate that I come here. What I have is a lot of slides actually, because one quote that I've heard before is “In God we trust, everyone else bring data.” And so I've tried to bring as much data as I could.
Now, one of the names of this talk is Intestinal Warfare, the role of fructooligosaccharides in health and disease. And I think, as you'll come to appreciate by the end of this talk, the health of the intestine does a lot to determine our overall health. Now, what we'll be doing in this talk is, we'll talk about nutraceuticals, we'll talk about probiotics briefly, prebiotics, a bit on safety and tolerance. Talk about how short chain FOS increases the number of bifidobacteria and also increases short chain fatty acids. And then we'll talk about applications in some of the more important diseases here, including lowering cholesterol, we’ll concentrate a bit on colon cancer. Just touch on ulcerative colitis, talk about calcium absorption and talk about the 20 years of Japanese experience with this product. And then finally conclude.
What are the Benefits of Nutraceutical Foods
I can't focus from here. So a nutraceutical is a food or food ingredient that's designed to provide medical or health benefits, including the prevention or treatment of disease. An example of this would be simply adding calcium to orange juice for example, as a way of preventing osteoporosis. So it's a fairly simple concept. Now, what I'm going to talk about, this is not at all an advertisement for Ensure. But what I'd like to show you is that, what I am going to talk about is shown here. And in a way it's kind of the main stream now and that a conservative pharmaceutical company is now using a nutraceutical product in 5 of its products. And it's shown here in Neutra-Flora FOS. And that's how I initially learned about it when I was in charge of nutritional products for Abbot International. This is the chemical structure. It’s quite simple. It's just a glucose molecule hooked between 2 and 4 fructose molecules. And these bonds are not digested by any of the enzymes in the small intestine. It really is only metabolized within the large intestine. This is the molecular structure of it. It's G…. You can see it's GF2 to GF3 GF4. Other products…like inulin or hydrolyzed inulin, also call themselves FOS, but what you're getting really I think is a mishmash of different things. And I think if