Fractionated Chemotherapy — also known as “low dose” chemo — differs from conventional cancer chemotherapy treatment in that the total dose of your chemotherapy is broken into smaller amounts and administered over a period of several days, rather than a single large dose.
This helps you by maximizing the dose intensity and exposing cancer cells within your body to the drugs for a longer period of time while reportedly reducing some of the unpleasant side effects of chemotherapy.
Cancers are caused by mutations that occur within cells and therefore selecting treatment based on mutations and not primary cancer site alone can provide advantages that may have gone overlooked. These strategies provide chemotherapy to patients while fasting, giving insulin or other biological response modifiers adjunctively prior to chemotherapy for enhanced targeting, and giving chemotherapy in micro-doses to allow for increased frequency of administration and the utilization of multiple targeted chemotherapeutic agents concurrently. 
Researchers have discovered numerous biomarkers and molecular changes that occur within a person’s cancer genetics that can be used to better target treatment. This method allows the use of multiple drugs in lower dosages to help reduce resistance, enhance targeting, and improve overall treatment.
Genetically Targeted Fractionated Chemotherapy
As time progresses, more biomarkers continue to be discovered which can lead to more targets for drugs either currently on the market or clinical trials. In addition to advancements made in the progression of cancer treatment with utilizing molecular profiles effectively, there are other therapeutic strategies that have been postulated as advanced effective ways to administer chemotherapy. 
Genetic molecular profiling is used to find patients' cancer cells. Next is targeting cancer cells via glucose metabolism. Glucose accelerates cancer (cancer gets its nutrients from glucose, therefore contains more insulin receptors) so this is one metabolic factor that distinguishes cancer cells from healthy cells. From a metabolic pattern, cancer cells have on average 12-36 times more insulin receptors that use glucose as their main source of energy.
Dr. Dino Prato focuses on Genetically Targeted Fractionated Chemotherapy (GTFC), an advanced form of chemo that applies molecular profiles, genetic typing, and targeted treatment, providing patients with alternatives. This method allows the use of multiple drugs in lower dosages to help reduce resistance, enhance targeting and improve overall treatment.
GTFC sessions are shorter and use lower dosages. Therefore, GTFC is much less taxing on the body. When combined with targeted immunotherapy and nutritional therapy, patients that utilize GTFC often claim they have more energy and feel healthier compared to the standard methods used. 
- Smith, A. , Oertle, J. and Prato, D. (2015) Genetically Targeted Fractionated Chemotherapy. Journal of Cancer Therapy, 6, 182-198. doi: 10.4236/jct.2015.62021
- Envita Medical Center | What is Genetically Targeted Fractionated Chemotherapy?