Insulin Potentiation Therapy (IPT)
++Insulin Potentiation Therapy (IPT)++ is a treatment where a cancer patient takes insulin with chemotherapy infusions. The insulin lets more of the chemotherapy drugs enter cells. This insulin used means that the patient needs lower doses of chemotherapy.
The goal of IPT is to have lower doses of chemotherapy with greater effectiveness against cancer. An idea sparked in the 1930s, IPT’s time may have come. IPT may not be right for every cancer patient, though.
IPT can carry the risks and side effects that come with insulin use in non-diabetic patients.
Learning about IPT, its potential, and its risks and side effects is essential to making informed health care decisions.
Found 2 Centers that offer Insulin Potentiation Therapy (IPT)
How Insulin Potentiation Therapy (IPT) works
What Research Says about Insulin Potentiation Therapy (IPT)
Multiple research studies involving IPT bring hope to cancer researchers. A ++2019 study++ shows insulin could be part of an effective treatment platform for colorectal cancer tumors. In patients with metastatic breast cancer, insulin plus methotrexate was shown to be more effective than methotrexate alone, according to a ++2004 study++.
IPT in the treatment of prostate tumors was the subject of a promising ++2012 study++.
However, other studies show that ++high levels of insulin++ in the blood can increase tumor growth. IPT would have to pinpoint the level of insulin needed to permeate cells more easily while not increasing the size of tumors.
Metformin, a treatment for Type 2 diabetes, has been shown to reduce the size of pancreatic tumors, according to a ++2009 study++.
++These discoveries suggest++ links between cancer, diabetes, insulin, and cancer treatments. Finding the right way to target cancer cells in each patient is vital.
History of Insulin Potentiation Therapy (IPT)
Dr. Donato Perez Garcia in Mexico developed Insulin Potentiation Therapy in Mexico. And he registered it with the U.S. Patent Office in 1939 as a treatment for syphilis and neurosyphilis. Now researchers think it may have the potential in fighting cancer.
The alternative cancer therapy is based on the idea that cancer cells consume more sugar than healthy cells in the body. If that is true, then those cells would be more sensitive to insulin. Insulin allows glucose to enter cells for energy and is thought to boost the permeability of cell membranes.
IPT hypothesizes that lower doses of chemotherapy would be needed since cancer cells would be more permeable because of insulin.
Research shows promise for IPT, but clinical trials of the therapy have not yet been conducted.
Since medications used in IPT are FDA-approved, IPT clinics use them “off-label” as a tool to fight cancer in their patients.
How To use Insulin Potentiation Therapy (IPT)
In the treatment, insulin is usually delivered through an injection or IV. With a dose of chemotherapy coming soon after. In IPT, professionals monitor the patient’s blood sugar. At the first signs of hypoglycemia, they administer glucose to avoid a dangerous drop in blood sugar caused by the insulin.
Researchers studying IPT are seeing ++promising results++. Still, the treatment has risks and side effects.
Risks / Side Effects of Insulin Potentiation Therapy (IPT)
Insulin isn’t without risks and side effects. People who do not have diabetes should not take insulin. It can send the body into a state of hypoglycemia where blood sugar levels drop to dangerously low levels. Symptoms of hypoglycemia include shock and seizures. Strokes, coma, and death can follow.
Side effects of IPT can include headaches and delirium from hypoglycemia.
Chemotherapy has side effects. These include vomiting, diarrhea, blisters, mouth sores, hair loss, fatigue, and infection. IPT could make lower doses of chemotherapy more effective. Which would lessen those side effects.
Anti-Cancer Benefits of Insulin Potentiation Therapy (IPT)
Insulin Potentiation Therapy makes cancer-fighting drugs more powerful in lower doses since it potentially makes it easier for chemotherapy to enter cancer cells. Since IPT can allow for low-dose chemotherapy, there are fewer side effects from those drugs.
Treatment plans for different types of cancer can include IPT. But patients with metastatic breast cancer, colon cancer, and prostate cancer may see the most benefit from IPT. Scientists may find more anti-cancer benefits of IPT after full-scale clinical trials are conducted.